Raman Spectroscopy

In biopharmaceutical manufacturing, the manufacturing processes can be extremely complex. These processes can rely heavily on living organisms to generate the end product. Subtle variations in the process environment can have a huge impact on yield and quality. The more one knows about the process, the more control that can be exercised.

Raman spectroscopy is one of the most powerful technologies that can be used to gain greater control of the processes. Raman spectroscopy offers real-time and accurate analysis of samples. Compact, easy-to-use and affordable, Raman Spectroscopy gives customers access to a system that allows processes to achieve faster cycle time, higher yield and better quality.

Raman Spectroscopy Probes

The energy from the laser light causes covalently bonded molecules in the sample to vibrate.  The Raman device detects this scattered light and interprets it to generate a “picture” called a Raman Spectrum.  The Raman Spectrum of a molecule is unique to that molecule and is similar to a molecular fingerprint.

Certain probe types allow for contact-free Raman measurements.

Uses for Raman Spectroscopy

Raman spectroscopy is both a qualitative and quantitative process. During the procedure, the probes collect information about a material’s chemical structure. Some information you can collect during Raman spectroscopy includes:

  • Intrinsic stress or strain.
  • Material impurities or contamination.
  • Material structure and identity.
  • Polymorphism and phase of materials.

The most significant use of Raman spectroscopy is in identifying materials. Since each material or molecule has a distinct Raman spectrum, you can quickly determine what a molecule is. 

Raman Spectroscopy From Sentinel Process Systems, Inc.

Sentinel Process Systems, Inc. has several types of Raman spectroscopy probes available, including contact BallProbes® and ContactFree Probes. We’ll help you choose the Raman probes that are most appropriate for your project. Contact us today to learn more.