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Corning – Advanced-Flow™ Reactors

 

Corning® Advanced-Flow™ Reactors are high-throughput, easily scalable reactors that are built around the same fundamental component – the integrated fluidic module, a meticulously engineered reactor plate made of either glass or silicon carbide – which allows for rapid and seamless scale-up from lab scale to commercial production.

Corning’s reactor technology offers dramatic savings in space, cost, and time while also enhancing purity, increasing yields, and substantially improving the quality, confidence in manufacturing, and economics of pharmaceutical manufacturing processes. These reactors are also inherently safer, more efficient, and more durable in corrosive conditions than other continuous flow reactors on the market today.

corning reactor corning reactors

Benefits of Corning Reactors

Corning® Advanced Flow™ Reactor Technology offers four key benefits over traditional batch processing:

  1. Inherently safer technology
  2. Better and more consistent product and process quality
  3. Lower OPEX and CAPEX
  4. Reduced environmental impact

These benefits are enabled by the:

  • Continuous and small-scale nature of Corning® Advanced Flow™ Reactor Technology, which allows for much lower reaction volumes (holdups) than batch reactors and is compatible with real-time, in-line monitoring.
  • Design of the fluidic modules, which facilitate better mixing, narrow residence time distribution, and superior heat and mass transfer than both batch reactors and other continuous flow reactors and can be readily reconfigured to meet the needs of thousands of different reactions at multiple scales.
  • Configuration of the reactors themselves, which are optimized to limit the potential impact of catastrophic events.
  • Quality of Corning’s materials, which are more resistant to corrosion and thermal shock than competitive materials used in similar configurations.

Corning Nebula™ Education Kits

The Corning® Advanced-Flow™ Reactor education platform – Corning Nebula™ Education Kits – enables colleges and universities to provide students in chemistry, chemical engineering, and related majors with inherently safer equipment to become proficient in flow chemistry and flow reactor operation. Corning Nebula Education Kits are available in two versions: (1) chemistry unit and (2) chemical engineering unit.

Corning Nebula™ Chemical Engineering Education Kit

Corning Nebula™ Chemical Engineering Education Kit

Unit Size: (L x W x H): 24.8” x 16.5” x 21.7” (63 x 42 x 55 cm)
Fluidic Module Size: 6.1” x 4.9” (155 x 125 mm)

Flow Rate Temperature Pressure Materials Fluidic Module Options
30 to 60 ml/min -5°C to 120°C 6 barg PP, PFA, Stainless steel, PPS, EPDM, Viton, PEEK, Perlast G75S O-rings, PTFE, glass 8.2 ml internal volume N.A.
Corning Nebula™ Chemistry Education Kit

Corning Nebula™ Chemistry Education Kit

Unit Size: (L x W x H): 24.8” x 16.5” x 21.7” (63 x 42 x 55 cm)

Fluidic Module Size: 6.1” x 4.9” (155 x 125 mm)

Flow Rate Temperature Pressure Materials Fluidic Module Options
30 to 60 ml/min -5°C to 120°C 6 barg disposable plastic or glass for syringe, ETFE, PFA, PTFE, Perlast G75S O-rings, glass 2.7 ml internal volume
  • 3rd pump
  • Gas line controller

Corning® Lab Reactor

The Corning® Lab Reactor has a metal free process fluid path that features a patented heart-cell channel design. The channel design provides outstanding mixing, heat exchange, as well as durability in most chemical systems. The reactor’s fluidic module is made of Corning specialty glass, providing a transparent window for chemists to see what’s happening inside. In addition, its “plug and play” open system includes data monitoring and storage, and easily connects with process analytical technology (PAT).

Corning lab reactor

Corning® Lab Reactor

Unit Size: (L x W x H): 17.7” x 18.9” x 20.5” (45 x 48 x 52 cm)
Fluidic Module Size: 6.1” x 4.9” (155 x 125 mm)

Flow Rate Temperature Pressure Materials Fluidic Module Options
2 to 10 ml/min -40°C to 200°C Up to 18 barg

Glass

PFA/PTFE

Perfluoroelastomer

2.7 ml internal volume
  • 3rd liquid dosing line
  • 2nd glass fluidic module
  • Lab Photo Reactor module

Corning® Lab Photo Reactor

The Corning® Lab Photo Reactor offers efficient light penetration with illumination on both sides of the glass fluidic module. The photo reactor also features a tunable LED irradiation source with six different wavelengths. The LED lighting intensity is higher than 100 mW/cm2. The Lab Photo Reactor also provides wireless control of wavelength selection and intensity.

Corning lab photo reactor

Corning® Lab Photo Reactor

Unit Size: (L x W x H): 15.7” x 15” x 17.7” (40 x 38 x 45 cm)
Fluidic Module Size: 6.1” x 4.9” (155 x 125 mm)

Flow Rate Temperature Pressure Materials Fluidic Module Options
2 to 10 ml/min -40°C to 200°C Up to 18 barg

Glass

PFA/PTFE

Perfluoroelastomer

2.7 ml internal volume

N.A.