Kilolabs - Pilot Plant Equipment

Chemtrix – Glass and Ceramic Reactors

The laboratory systems consist of Labtrix®, GramFlow® and KiloFlow® and are based on glass reactors that have chemical compatibility and optical transparency. The systems for industrial scale continuous manufacturing include Protrix and Plantrix®, and are based on 3M™ Silicon Carbide reactors selected for their superior chemical flexibility and high corrosion resistance.
Chemtrix has developed a comprehensive, easy to scale product portfolio for continuous processing from laboratory scale to industrial production scale. The Chemtrix reactor solutions are well suited for the pharmaceutical and fine chemicals industry.

The Chemtrix reactors provide several key advantages:
  • Safe use of more extreme reaction conditions (even for dangerous reactions)
  • Increased selectivity of reactions; a reduction in the use of raw materials and energy with reduced waste production
  • Decrease in development time; a shorter experiment time, no need for scale-up
  • Reduction in product lead time; combination of more synthetic steps in a single micro reactor
  • Scale up issues are minimized due to maintaining excellent mixing and heat transfer
  • Higher flow rates and correspondingly larger reactors can be used to easily produce kilogram or tonne-scale quantities
Laboratory Reactors

Labtrix Start reactor is a manually operated plug-and-play continuous flow reaction system for lab-based reaction screening and process optimization

  • Modular setup with easy exchange of components for increased chemical compatibility, number of feed lines, or reactor type/volume
  • Allows assessment of continuous process feasibility
  • Ideal for use in higher education, training and commercial applications

Labtrix S1 reactor is an automated plug-and-play continuous flow reaction system used for process optimization and validation, exploration of novel reaction conditions, and lab-based reaction screening.

  • Multiple reactor designs and volumes to suit different application types
  • Dedicated software provides automatic data-logging, sample collection, and control
  • Automated operation generates reliable, reproducible data for scale-up
  • Ideal for use in higher education, training and commercial applications

GramFlow reactor is an automated system that uses a zig-zag structure to achieve thorough and reliable fluid mixing.

  • Scale up from mg to 1,200 grams per day
  • Integrated pre-heat and heat exchange for optimal thermal control
  • Reaction screening and g-scale production
  • Ideal for use in training and commercial applications

KiloFlow reactor is an automated reactor that provides larger reaction development within a standard fume hood and offers kilogram- scale production

  • Modular, scalable flow reactor system with ml glass reactors and integrated heat exchangers configurable for different applications
  • Flexible process capacity between 100 grams and 140 kilograms per day
  • Works with standard lab pumps and temperature controls.
  • Ideal for use in commercial applications

 

Industrial Scale Reactors

Protrix and Plantrix reactors incorporate ceramic silicon carbide for extreme tolerance and resistance to aggressive acidic conditions, even at high heat. These reactors proved superior corrosion resistance and allow rapid transition from lab-scale to industrial-scale applications.

  • Fully automated systems
  • 3M advanced ceramics diffusion bonding holds plates together without cement or gaskets
  • 5x greater conductivity than Hastelloy or steel, ensuring uniform heat transfer
  • Protrix reactors scale directly to Plantrix MR 555 platform (340x scale-up), allowing quick transition from gram-scale development to ton-scale production

 

Chemtrix Product Range
Model Flowrate Range Internal Vol Reactor Type Temp Range Pressure (bar)
Labtrix 0.1 – 100 ul/min 1 to 19.5 ul Glass -50°C – 195°C 20
Labtrix S1 0.1 – 100 ul/min 1 to 19.5 ul Glass -50°C – 195°C 20
Gram Flow 0.2 – 10 ml/min 1 ml Glass -50°C – 150°C 20
Kilo Flow 0.2 – 100 ml/min 0.8 – 18 ml Glass -20°C – 150°C 20
Protrix 0.2 – 20 ml/min 1 – 13.5 ml 3M Silicone Carbide -20°C – 150°C 25
Plantrix – MR260 1 – 36 l/hr 2.9 – 170 ml 3M Silicone Carbide -30°C – 200°C 25
Plantrix – MR555 5 – 400 l/hr 100 ml – 4 l 3M Silicone Carbide -30°C – 200°C 25

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